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Review
. 2020 Aug 26;12(8):721-730.
doi: 10.4252/wjsc.v12.i8.721.

Off-the-shelf mesenchymal stem cells from human umbilical cord tissue can significantly improve symptoms in COVID-19 patients: An analysis of evidential relations

Phuc Van Pham  1 , Ngoc Bich Vu  1
Affiliations
Review

Off-the-shelf mesenchymal stem cells from human umbilical cord tissue can significantly improve symptoms in COVID-19 patients: An analysis of evidential relations

Phuc Van Pham et al. World J Stem Cells. .

Abstract

Coronavirus disease-2019 (COVID-19) has affected more than 200 countries worldwide. This disease has hugely affected healthcare systems as well as the economy to an extent never seen before. To date, COVID-19 infection has led to about 165000 deaths in 150 countries. At present, there is no specific drug or efficient treatment for this disease. In this analysis based on evidential relationships of the biological characteristics of MSCs, especially umbilical cord (UC)-derived MSCs as well as the first clinical trial using MSCs for COVID-19 treatment, we discuss the use of UC-MSCs to improve the symptoms of COVID-19 in patients.

Keywords: COVID-19; Coronavirus; Mesenchymal stem cells; Umbilical cord-derived mesenchymal stem cells.

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Conflict of interest statement

Conflict-of-interest statement: The author(s) declare that they have no competing interests.

Figures

Figure 1
Figure 1
Possible mechanisms of mesenchymal stem cells in coronavirus disease-2019 treatment. Mesenchymal stem cells directly affect novel coronavirus, affect the immune system of patients, and stimulate wound healing.
Figure 2
Figure 2
Workflow of umbilical cord-derived mesenchymal stem cell manufacturing. Donors are screened for some viruses and genetic disorders. Then, accepted umbilical cords are used to isolate umbilical cord-derived mesenchymal stem cells (UC-MSCs) for harvest at passage 2–3 to produce the master cell bank. A working bank of UC-MSCs is produced from the master bank before expanding UC-MSCs to obtain enough cells for transplantation. HIV: Human immunodeficiency virus; HBV: Hepatitis B virus; HCV: Hepatitis C virus.
See this image and copyright information in PMC

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