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. 2020 Apr 24;54(Suppl 1):76-80.
doi: 10.1007/s43465-020-00120-8. eCollection 2020 Sep.

Plasma d-Dimer Levels in Non-prosthetic Orthopaedic Implant Infection: Can it Aid Diagnosis?

Govind Karunakaran  1 , Jagdish Menon  1 , Sandeep Nema  1 , Debadatta Basu  2
Affiliations

Plasma d-Dimer Levels in Non-prosthetic Orthopaedic Implant Infection: Can it Aid Diagnosis?

Govind Karunakaran et al. Indian J Orthop. .

Abstract

Purpose: d-Dimer estimation has been proposed as a reliable biomarker in prosthetic joint infections. Its role in non-prosthetic orthopaedic implant infections has, however, not been studied. The objectives of this study were to assess the levels of plasma d-Dimer in non-prosthetic orthopaedic implant infection. The diagnostic efficiency of d-dimer on orthopaedic implant-related infection was evaluated.

Methods: The study was designed as a cross-sectional comparative study. Patients who presented with orthopaedic implant-related infection as diagnosed by modified MSIS criteria were allocated to case group (n = 49) and patients who underwent surgical procedures with orthopaedic implants with no evidence of infection at 6 weeks postoperatively were allocated to the control group (n = 48). Serum d-Dimer levels were assessed quantitatively using immunoturbidimetric assays in both groups and compared between both groups.

Results: The mean (± SD) value of serum d-Dimer in case group was 0.64 (± 0.45) μg/ml and control group was 0.77 (± 0.47) μg/ml. No significant difference was found in serum d-Dimer levels between cases and control groups (p value = 0.183). The diagnostic accuracy of d-dimer in orthopaedic implant-related infection also could not be demonstrated.

Conclusion: The findings of d-dimer as a marker for the diagnosis of prosthetic joint infections cannot be extrapolated to non-prosthetic orthopaedic implant infection.

Keywords: Biomarkers; Implant associated infection; Internal fixation; d-dimer.

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Conflict of interest statement

Conflict of InterestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Receiver operating characteristic (ROC) curve assessing diagnostic accuracy of plasma d-dimer in orthopaedic implant-related infections
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References

    1. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine. 1999;340:448. doi: 10.1056/NEJM199902113400607. - DOI - PubMed
    1. Antoniak S. The coagulation system in host defense. Research and Practice in Thrombosis and Haemostasis. 2018;2(3):549–557. doi: 10.1002/rth2.12109. - DOI - PMC - PubMed
    1. Weitz JI, Fredenburgh JC, Eikelboom JW. A test in context: d-dimer. Journal of the American College of Cardiology. 2017;70(19):2411–2420. doi: 10.1016/j.jacc.2017.09.024. - DOI - PubMed
    1. Shahi A, Kheir MM, Tarabichi M, Hosseinzadeh HRS, Tan TL, Parvizi J. Serum d-dimer test is promising for the diagnosis of periprosthetic joint infection and timing of reimplantation. The Journal of Bone and Joint Surgery. 2017;99(17):1419–1427. doi: 10.2106/JBJS.16.01395. - DOI - PubMed
    1. Goebel PJ, Williams JB, Gerhardt RT. A pilot study of the performance characteristics of the d-dimer in presumed sepsis. The Western Journal of Emergency Medicine. 2010;2:7. - PMC - PubMed

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