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. 2020 Sep 1:2020:8610903.
doi: 10.1155/2020/8610903. eCollection 2020.

Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study

Derya Uluduz  1 , Sevki Sahin  2 , Taskin Duman  3 , Serefnur Ozturk  4 , Vildan Yayla  5 , Nazire Afsar  6 , Nevzat Uzuner  7 , Ipek Midi  8 , Nilgun Cinar  2 , Mehmet Ali Sungur  9 , Fusun Mayda Domac  10 , Birsen Ince  1 , Baki Goksan  1 , Cemile Handan Misirli  11 , Mustafa Bakar  12 , Hasan Huseyin Kozak  13 , Sena Colakoglu  3 , Ali Yavuz Karahan  14 , Eylem Ozaydin Goksu  15 , Fatih Ozdag  16 , Mehmet Guney Senol  16 , Vedat Ali Yurekli  17 , Ufuk Aluclu  18 , Serkan Demir  19 , Hayriye Kucukoglu  20 , Serdar Oruc  21 , Nilufer Yesilot  22 , Ozge Yimaz Kusbeci  23 , Bijen Nazliel  24 , Firdevs Ezgi Ucan Tokuc  15 , Hesna Bektas  25 , Fatma Nida Tascilar  26 , Emrah Aytac  27 , Mustafa Gokce  28 , Hale Zeynep Batur Caglayan  24 , Ahmet Tufekci  29 , Gulnur Uzuner  7 , Dilek Necioglu Orken  30 , Osman Ozgur Yalin  31 , Uygar Utku  28 , Arda Yilmaz  32 , Hamit Genc  32 , Murat Cabalar  33 , Aysel Milanlioglu  34 , Hakan Ekmekci  4 , Burcu Zeydan  35 , Sevim Baybas  36 , Yuksel Kablan  37 , Basak Karakurum Goksel  38 , Mustafa Acikgoz  26 , Hatice Kurucu  1 , Seden Demirci  39 , Taskin Gunes  40
Affiliations

Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study

Derya Uluduz et al. Stroke Res Treat. .

Abstract

Background: Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.

Methods: Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.

Results: The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34 ± 9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 ± 9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).

Conclusion: The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.

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Conflict of interest statement

The authors declared that they have no conflicts of interest for this article.

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