Romosozumab, clinical trials, and real-world care of patients with osteoporosis
- PMID: 32953774
- PMCID: PMC7475409
- DOI: 10.21037/atm.2020.03.196
Romosozumab, clinical trials, and real-world care of patients with osteoporosis
Conflict of interest statement
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm.2020.03.196). EML has no direct income from potentially conflicting entities. His employer, New Mexico Clinical Research & Osteoporosis Center, has received research grants from Radius, Amgen, Mereo, Bindex; income for service on scientific advisory boards or consulting for Amgen, Radius, Alexion, Sandoz, Samsung Bioepis, Sanifit; service on speakers’ bureaus for Radius, Alexion; project development for University of New Mexico; and royalties from UpToDate for sections on DXA, fracture risk assessment, and prevention of osteoporosis. He is a board member of the National Osteoporosis Foundation, International Society for Clinical Densitometry, and Osteoporosis Foundation of New Mexico.
Comment on
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Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study.J Bone Miner Res. 2018 Aug;33(8):1397-1406. doi: 10.1002/jbmr.3452. Epub 2018 May 22. J Bone Miner Res. 2018. PMID: 29694685 Clinical Trial.
References
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- International Osteoporosis Foundation. Facts and statistics 2020 February 21, 2020. Available online: https://www.iofbonehealth.org/facts-statistics#category-14
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- Langdahl BL, Libanati C, Crittenden DB, et al. Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial. Lancet 2017;390:1585-94. 10.1016/S0140-6736(17)31613-6 - DOI - PubMed
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