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Case Reports
. 2020 Jun 18;5(9):1576-1580.
doi: 10.1016/j.ekir.2020.06.010. eCollection 2020 Sep.

Tubulointerstitial Nephritis Cases With IgM-Positive Plasma Cells

Natsumi Matsuoka-Uchiyama  1 , Kenji Tsuji  1 , Kazuhiko Fukushima  1 , Shinji Kitamura  1 , Haruhito A Uchida  2 , Hitoshi Sugiyama  3 , Naoki Takahashi  4 , Masayuki Iwano  4 , Jun Wada  1
Affiliations
Case Reports

Tubulointerstitial Nephritis Cases With IgM-Positive Plasma Cells

Natsumi Matsuoka-Uchiyama et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
The second renal biopsy and liver biopsy findings in case 1. (a) Light microscopy image with periodic acid−Schiff stain, showing massive inflammatory cell infiltration in renal tubulointerstitium. Original magnification ×400. (b) Image of staining of IgG4, showing no infiltration by IgG4-positive plasma cells. Original magnification ×100. (c) Image of dual staining of CD138 (brown) and IgM (pink), showing the extent of IgM-CD138 dual-positive plasma cell infiltration. Original magnification ×100. (d) Image of dual staining of CD138 (brown) and IgM (pink), showing massive infiltration by IgM-CD138 dual-positive plasma cells in renal interstitium. Red arrows show representative IgM-CD138 dual-positive cells. Original magnification ×400. (e) Light microscopy image with hematoxylin and eosin stain, showing nonsuppurative destructive cholangitis in the liver. Original magnification ×200. (f) Image of dual staining of CD138 (brown) and IgM (pink), showing massive infiltration by IgM-CD138 dual-positive plasma cells in liver. Red arrows show representative IgM-CD138 dual-positive cells. Original magnification ×400.
Figure 2
Figure 2
The second renal biopsy and liver biopsy findings in case 2. (a) Light microscopy image with periodic acid–Schiff stain, showing massive inflammatory cell infiltration in renal tubulointerstitium. Original magnification ×400. (b) Image of staining of IgG4, showing no infiltration by IgG4-positive plasma cells. Original magnification ×100. (c) Image of dual staining of CD138 (brown) and IgM (pink), showing the extent of IgM-CD138 dual-positive plasma cell infiltration. Original magnification ×100. (d) Image of dual staining of IgM (pink) and CD138 (brown), showing massive infiltration by IgM-CD138 dual-positive plasma cells in renal interstitium. Red arrows show representative IgM-CD138 dual-positive cells. Original magnification ×400.
See this image and copyright information in PMC

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