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Comparative Study
. 2021 Jan;53(1):165-169.
doi: 10.1007/s11255-020-02646-0. Epub 2020 Sep 20.

Correlation between laboratory parameters on admission and outcome of COVID-19 in maintenance hemodialysis patients

Weifeng Shang  1 , Yuanyuan Li  2 , Hua Li  1 , Wei Li  1 , Chengxu Li  1 , Yuan Cai  1 , Junwu Dong  3
Affiliations
Comparative Study

Correlation between laboratory parameters on admission and outcome of COVID-19 in maintenance hemodialysis patients

Weifeng Shang et al. Int Urol Nephrol. 2021 Jan.

Abstract

Purpose: This present study aims to investigate the relationship between laboratory parameters on admission and prognosis of coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, as well as providing a theoretical basis for clinical evaluation of prognosis and corresponding intervention measures.

Methods: Retrospective analysis was performed on the clinical data of 47 maintenance hemodialysis patients who infected with COVID-19 and admitted to our hospital. According to their clinical outcome, these patients were divided into a survival group (n = 38) and a fatality group (n = 9). Information on the general condition and laboratory parameters of the patients were collected. Laboratory parameters were compared between different groups. The area under the curve (AUC) was used to evaluate the prognosis of COVID-19 in maintenance hemodialysis patients.

Results: Statistically significant differences were observed in age, white blood cell count, neutrophil count, albumin, C-reactive protein (CRP), procalcitonin, and lactate dehydrogenase (LDH) on admission (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the values of AUC of CRP, neutrophil count, LDH, white blood cell count, albumin, and procalcitonin were 0.895, 0.813, 0.758, 0.757, 0.743, and 0.728, respectively.

Conclusions: Laboratory parameters including CRP, neutrophil count, LDH, white blood cell count, albumin, and procalcitonin were predictive on the prognosis of maintenance hemodialysis patients with COVID-19. Among them, CRP was the strongest single predictive laboratory indicator.

Keywords: Coronavirus disease 2019; Hemodialysis; Laboratory parameters; Novel coronavirus pneumonia.

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Conflict of interest statement

The authors declare that they have no competing interests.

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