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Comment
. 2021 Jan 1;203(1):139-140.
doi: 10.1164/rccm.202007-2924LE.

Is IL-6 the Right Target in COVID-19 Severe Pneumonia?

Mathieu Blot  1   2 , Abderrahmane Bourredjem  3 , Christine Binquet  2   3 , Lionel Piroth  1   3 ; LYMPHONIE Study Group
Collaborators, Affiliations
Comment

Is IL-6 the Right Target in COVID-19 Severe Pneumonia?

Mathieu Blot et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Box plot showing the plasma concentration of IL-6 within 48 hours of hospitalization in 36 patients with non–COVID-19 and 27 patients with COVID-19 severe pneumonia (LYMPHONIE study, 2018–2020). COVID-19 = coronavirus disease.
See this image and copyright information in PMC

Comment in

  • Reply to Blot et al. and to Inoue et al.
    McElvaney OJ, McEvoy NL, McElvaney NG, Curley GF. McElvaney OJ, et al. Am J Respir Crit Care Med. 2021 Jan 1;203(1):141-142. doi: 10.1164/rccm.202008-3169LE. Am J Respir Crit Care Med. 2021. PMID: 32955924 Free PMC article. No abstract available.

Comment on

  • Characterization of the Inflammatory Response to Severe COVID-19 Illness.
    McElvaney OJ, McEvoy NL, McElvaney OF, Carroll TP, Murphy MP, Dunlea DM, Ní Choileáin O, Clarke J, O'Connor E, Hogan G, Ryan D, Sulaiman I, Gunaratnam C, Branagan P, O'Brien ME, Morgan RK, Costello RW, Hurley K, Walsh S, de Barra E, McNally C, McConkey S, Boland F, Galvin S, Kiernan F, O'Rourke J, Dwyer R, Power M, Geoghegan P, Larkin C, O'Leary RA, Freeman J, Gaffney A, Marsh B, Curley GF, McElvaney NG. McElvaney OJ, et al. Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821. doi: 10.1164/rccm.202005-1583OC. Am J Respir Crit Care Med. 2020. PMID: 32584597 Free PMC article.

References

    1. McElvaney OJ, McEvoy NL, McElvaney OF, Carroll TP, Murphy MP, Dunlea DM, et al. Characterization of the inflammatory response to severe COVID-19 illness. Am J Respir Crit Care Med. 2020;202:812–821. - PMC - PubMed
    1. Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146:110–118. - PMC - PubMed
    1. Wang C, Fei D, Li X, Zhao M, Yu K. IL-6 may be a good biomarker for earlier detection of COVID-19 progression. Intensive Care Med. 2020;46:1475–1476. - PMC - PubMed
    1. Sinha P, Matthay MA, Calfee CS. Is a “cytokine storm” relevant to COVID-19? JAMA Intern Med. [online ahead of print] 30 Jun 2020; DOI: 10.1001/jamainternmed.2020.3313. - PubMed

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