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Lael M Yonker¹, Anne M Neilan², Yannic Bartsch³, Ankit B Patel⁴, James Regan⁵, Puneeta Arya⁶, Elizabeth Gootkind⁷, Grace Park⁷, Margot Hardcastle⁷, Anita St John⁷, Lori Appleman⁷, Michelle L Chiu⁶, Allison Fialkowski⁸, Denis De la Flor⁹, Rosiane Lima⁹, Evan A Bordt⁶, Laura J Yockey¹⁰, Paolo D'Avino¹¹, Stephanie Fischinger¹², Jessica E Shui⁶, Paul H Lerou⁶, Joseph V Bonventre⁴, Xu G Yu¹³, Edward T Ryan¹⁴, Ingrid V Bassett¹⁵, Daniel Irimia¹⁶, Andrea G Edlow¹⁷, Galit Alter¹⁸, Jonathan Z Li¹⁹, Alessio Fasano¹

Affiliations

¹ Mucosal Immunology and Biology Research Center; Department of Pediatrics, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
² Department of Pediatrics; Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
³ Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts; Harvard Medical School, Boston, Massachusetts.
⁴ Renal Division, Department of Medicine, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.
⁵ Department of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
⁶ Department of Pediatrics, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
⁷ Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
⁸ Harvard Medical School, Boston, Massachusetts.
⁹ Mucosal Immunology and Biology Research Center; Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
¹⁰ Department of Internal Medicine; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA.
¹¹ Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts.
¹² Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts.
¹³ Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts; Department of Infectious Diseases, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁴ Department of Pediatrics; Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
¹⁵ Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁶ Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁷ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology; Vincent Center for Reproductive Biology, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁸ Vincent Center for Reproductive Biology, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁹ Department of Infectious Diseases, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.

PMID: 32956696
PMCID: PMC7500434
DOI: 10.1016/j.jpeds.2020.09.035

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Lael M Yonker et al. J Pediatr. 2021 Jan.

. 2021 Jan:228:320-323.

doi: 10.1016/j.jpeds.2020.09.035. Epub 2020 Sep 18.

Authors

Affiliations

¹ Mucosal Immunology and Biology Research Center; Department of Pediatrics, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
² Department of Pediatrics; Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
³ Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts; Harvard Medical School, Boston, Massachusetts.
⁴ Renal Division, Department of Medicine, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.
⁵ Department of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
⁶ Department of Pediatrics, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
⁷ Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
⁸ Harvard Medical School, Boston, Massachusetts.
⁹ Mucosal Immunology and Biology Research Center; Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
¹⁰ Department of Internal Medicine; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA.
¹¹ Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts.
¹² Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts.
¹³ Ragon Institute of Massachusetts General Hospital, MIT and Harvard Medical School, Cambridge, Massachusetts; Department of Infectious Diseases, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁴ Department of Pediatrics; Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
¹⁵ Department of Internal Medicine, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁶ Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁷ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology; Vincent Center for Reproductive Biology, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁸ Vincent Center for Reproductive Biology, Massachusetts General Hospital; Harvard Medical School, Boston, Massachusetts.
¹⁹ Department of Infectious Diseases, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.

PMID: 32956696
PMCID: PMC7500434
DOI: 10.1016/j.jpeds.2020.09.035

No abstract available

PubMed Disclaimer

Comment on

Comment regarding pediatric severe acute respiratory syndrome coronavirus 2: clinical presentation, infectivity, and immune responses.
Ferranti JF, Degaspare NV, Mau LB, Delgado AF, Brunow de Carvalho W. Ferranti JF, et al. J Pediatr. 2021 Jan;228:319-320. doi: 10.1016/j.jpeds.2020.09.034. Epub 2020 Sep 18. J Pediatr. 2021. PMID: 32956699 Free PMC article. No abstract available.

References

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1. Han M.S., Choi E.H., Chang S.H., Jin B.L., Lee E.J., Kim B.N. Clinical characteristics and viral RNA detection in children with coronavirus disease 2019 in the Republic of Korea. JAMA Pediatr. 2020:e203988. - PMC - PubMed
1. Wei W.E., Li Z., Chiew C.J., Yong S.E., Toh M.P., Lee V.J. Presymptomatic transmission of SARS-CoV-2—Singapore, January 23-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:411–415. - PMC - PubMed
1. He X., Lau E.H.Y., Wu P., Deng X., Wang J., Hao X. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672–675. - PubMed
1. Heald-Sargent T., Muller W.J., Zheng X., Rippe J., Patel A.B., Kociolek L.K. Age-related differences in nasopharyngeal severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease 2019 (COVID-19) JAMA Pediatr. 2020;174:902–903. - PMC - PubMed

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