Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years?

doi:10.3390/diagnostics10090706

Review

. 2020 Sep 17;10(9):706.

doi: 10.3390/diagnostics10090706.

Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years?

Bogdan Doroftei^{1

2

3}, Ana-Maria Dabuleanu^{1

2

3}, Ovidiu-Dumitru Ilie⁴, Radu Maftei^{1

2

3}, Emil Anton^{1

2

3}, Gabriela Simionescu^{1

2

3}, Theodor Matei^{2

3}, Theodora Armeanu^{2

3}

Affiliations

¹ Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
² Clinical Hospital of Obstetrics and Gynecology "Cuza Voda", Cuza Voda Street, No. 34, 700038 Iasi, Romania.
³ Origyn Fertility Center, Palace Street, No. 3C, 700032 Iasi, Romania.
⁴ Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Carol I Avenue, No. 20A, 700505 Iasi, Romania.

PMID: 32957624
PMCID: PMC7554703
DOI: 10.3390/diagnostics10090706

Review

Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years?

Bogdan Doroftei et al. Diagnostics (Basel). 2020.

. 2020 Sep 17;10(9):706.

doi: 10.3390/diagnostics10090706.

Authors

Affiliations

¹ Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
² Clinical Hospital of Obstetrics and Gynecology "Cuza Voda", Cuza Voda Street, No. 34, 700038 Iasi, Romania.
³ Origyn Fertility Center, Palace Street, No. 3C, 700032 Iasi, Romania.
⁴ Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Carol I Avenue, No. 20A, 700505 Iasi, Romania.

PMID: 32957624
PMCID: PMC7554703
DOI: 10.3390/diagnostics10090706

Abstract

Asherman syndrome is a multifaceted condition describing the partial or complete removal of the uterine cavity and/or cervical canal. It is a highly debatable topic because of its pronounced influence on both reproductive outcomes and gynaecologic symptoms. The latest reports demonstrated that trauma to the endometrium is the main cause of intrauterine adhesion formation. Left untreated, such adhesions gradually lead to a range of repercussions ranging from mild to severe. Considering the lack of non-invasive approaches, the advent of hysteroscopy has revolutionized the entire field, being otherwise considered the most efficient tool offering new directions and amplifying the chances of treating the Asherman syndrome.

Keywords: Asherman syndrome; hysteroscopy; intrauterine adhesions; intrauterine synechiae.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

1. Fritsch H. Ein Fall von volligen schwund der Gebaumutterhohle nach Auskratzung. Zentralbl Gynaekol. 1894;18:1337–1342.
1. Bass B. Ueber die Verwachsungen in der cervix uterinach curettagen. Zentralbl Gynakol. 1927;51:223.
1. Stamer S. Partial and total Atresia of the Uterus after Excochleation. Acta Obstet. Gynecol. Scand. 1946;26:263–297. doi: 10.3109/00016344609154456. - DOI
1. Yu D., Wong Y.-M., Cheong Y., Xia E., Li T.-C. Asherman syndrome--one century later. Fertil. Steril. 2008;89:759–779. doi: 10.1016/j.fertnstert.2008.02.096. - DOI - PubMed
1. Conforti A., Alviggi C., Mollo A., De Placido G., Magos A. The management of Asherman syndrome: A review of literature. Reprod. Biol. Endocrinol. 2013;11:118. doi: 10.1186/1477-7827-11-118. - DOI - PMC - PubMed

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[1] Fritsch H. Ein Fall von volligen schwund der Gebaumutterhohle nach Auskratzung. Zentralbl Gynaekol. 1894;18:1337–1342.

[2] Fritsch H. Ein Fall von volligen schwund der Gebaumutterhohle nach Auskratzung. Zentralbl Gynaekol. 1894;18:1337–1342.

[3] Bass B. Ueber die Verwachsungen in der cervix uterinach curettagen. Zentralbl Gynakol. 1927;51:223.

[4] Bass B. Ueber die Verwachsungen in der cervix uterinach curettagen. Zentralbl Gynakol. 1927;51:223.

[5] Stamer S. Partial and total Atresia of the Uterus after Excochleation. Acta Obstet. Gynecol. Scand. 1946;26:263–297. doi: 10.3109/00016344609154456. - DOI

[6] Stamer S. Partial and total Atresia of the Uterus after Excochleation. Acta Obstet. Gynecol. Scand. 1946;26:263–297. doi: 10.3109/00016344609154456. - DOI

[7] Yu D., Wong Y.-M., Cheong Y., Xia E., Li T.-C. Asherman syndrome--one century later. Fertil. Steril. 2008;89:759–779. doi: 10.1016/j.fertnstert.2008.02.096. - DOI - PubMed

[8] Yu D., Wong Y.-M., Cheong Y., Xia E., Li T.-C. Asherman syndrome--one century later. Fertil. Steril. 2008;89:759–779. doi: 10.1016/j.fertnstert.2008.02.096. - DOI - PubMed

[9] Conforti A., Alviggi C., Mollo A., De Placido G., Magos A. The management of Asherman syndrome: A review of literature. Reprod. Biol. Endocrinol. 2013;11:118. doi: 10.1186/1477-7827-11-118. - DOI - PMC - PubMed

[10] Conforti A., Alviggi C., Mollo A., De Placido G., Magos A. The management of Asherman syndrome: A review of literature. Reprod. Biol. Endocrinol. 2013;11:118. doi: 10.1186/1477-7827-11-118. - DOI - PMC - PubMed

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Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years?

Affiliations

Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years?

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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