Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 22:26:e927913.
doi: 10.12659/MSM.927913.

Urachal Carcinoma: Are Lymphadenectomy and Umbilectomy Necessary?

Zhuo Jia  1 , Xiao Chang  1 , Xing Li  1 , Baojun Wang  1 , Xu Zhang  1
Affiliations

Urachal Carcinoma: Are Lymphadenectomy and Umbilectomy Necessary?

Zhuo Jia et al. Med Sci Monit. .

Abstract

BACKGROUND The aim of this study was to explore the impact of lymphadenectomy and umbilectomy on long-term survival and progression-free survival (PFS) of patients with urachal carcinoma. MATERIAL AND METHODS We performed a retrospective analysis of 39 patients with urachal carcinoma. Clinicopathologic outcomes were evaluated, and overall survival (OS) and PFS were assessed by Kaplan-Meier method and Cox regression analysis. RESULTS Thirty-four (87.2%) patients underwent partial cystectomy, and 3 (7.7%) patients underwent radical cystectomy with en bloc urachal resection. Eighteen (46.2%) patients underwent lymphadenectomy and 27 (69.2%) patients had umbilectomy. Multivariate analysis showed that tumor size (P=0.011), Mayo stage (P=0.012), and umbilectomy (P=0.007) were the independent prognostic factors for OS. The median overall survival time was 67 months. The differentiation degree of tumor (P=0.049), Mayo stage (P=0.004), and umbilectomy (P=0.046) were the independent prognostic factors for PFS. Lymph node resection was not a predictor of OS. Patients had poorer prognosis when the tumor invaded the entire wall, including the mucous layer, muscular layer, and serous layer of the bladder compared with those that invaded only the muscular layer (P=0.014). CONCLUSIONS Lymph node metastases and failure to undergo umbilectomy were the independent prognostic factors for OS and PFS. Lymph node resection was not a predictor of OS. Patients had poorer prognosis when the tumor invaded the entire wall of the bladder compared with those that invaded the muscular layer.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

None.

Figures

Figure 1
Figure 1
Overall survival by lymph node status.
Figure 2
Figure 2
Overall survival of tumor invading muscular layer and entire bladder wall.
Figure 3
Figure 3
Overall survival by tumor progression.
Figure 4
Figure 4
Progression-free survival by lymph node status.
See this image and copyright information in PMC

References

    1. Paras FA, Jr, Maclennan GT. Urachal adenocarcinoma. J Urol. 2008;180(2):720. - PubMed
    1. Szarvas T, Módos O, Niedworok C, et al. Clinical, prognostic, and therapeutic aspects of urachal carcinoma-A comprehensive review with meta-analysis of 1,010 cases. Urol Oncol. 2016;34(9):388–98. - PubMed
    1. Munichor M, Szvalb S, Cohen H, et al. Mixed adenocarcinoma and neuroendocrine carcinoma arising in the urachus. A case report and review of the literature. Eur Urol. 1995;28(4):345–47. - PubMed
    1. Ghazizadeh M, Yamamoto S, Kurokawa K. Clinical features of urachal carcinoma in Japan: Review of 157 patients. Urol Res. 1983;11(5):235–38. - PubMed
    1. Chen D, Li Y, Yu Z, et al. Investigating urachal carcinoma for more than 15 years. Oncol Lett. 2014;8(5):2279–83. - PMC - PubMed

Supplementary concepts