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Review
. 2021 May;26(3):e12798.
doi: 10.1111/anec.12798. Epub 2020 Sep 21.

Successful treatment of arrhythmia with β-blocker and flecainide combination in pregnant patients with Andersen-Tawil syndrome: A case report and literature review

Pongprueth Rujirachun  1 , Apichaya Junyavoraluk  1 , Manop Pithukpakorn  2   3 , Bhoom Suktitipat  3   4 , Arjbordin Winijkul  5
Affiliations
Review

Successful treatment of arrhythmia with β-blocker and flecainide combination in pregnant patients with Andersen-Tawil syndrome: A case report and literature review

Pongprueth Rujirachun et al. Ann Noninvasive Electrocardiol. 2021 May.

Abstract

Andersen-Tawil syndrome (ATS) is a rare disorder characterized by a triad of ventricular arrhythmia (VA), dysmorphic features, and periodic paralysis. Due to the rarity of this condition, less is known about physiologic effect of pregnancy to ATS and arrhythmia. There is no established guideline for peripartum or postpartum treatment and prevention of arrhythmia in ATS; thus, the clinical management is challenging. We reported two KCNJ2-associated ATS patients who got pregnant and underwent vaginal birth safely. Both individuals had VA, micrognathia without periodic paralysis. β-blocker plus flecainide could be an effective treatment combination when monotherapy failed to control arrhythmia. VA of two pregnant patients with ATS could be controlled by either physiologic changes associated pregnancy or the combination treatment of β-blocker and flecainide.

Keywords: Andersen-Tawil syndrome; case report; flecainide; pregnancy; β-blocker.

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Conflict of interest statement

The authors have declared that no conflict of interests exist.

Figures

Figure 1
Figure 1
Family pedigree. The proband (ATS‐003) is indicated by the arrow. Family members with Andersen–Tawil syndrome (ATS) are illustrated as a red color (ATS‐001 and ATS‐002). Unaffected family members are illustrated as open symbols. A circle represents a female, and a square represents a male
Figure 2
Figure 2
Twelve‐lead electrocardiography (ECG) demonstrating (a) polymorphic VT and (b) normal sinus rhythm
Figure 3
Figure 3
Twelve‐lead electrocardiography (ECG) demonstrating (a) incessant bidirectional VT, (b) sinus rhythm with prominent U wave and occasional premature ventricular contractions (PVCs), and (c) normal sinus rhythm
See this image and copyright information in PMC

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