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Case Reports
. 2021 Apr;23(2):e13470.
doi: 10.1111/tid.13470. Epub 2020 Sep 29.

Successfully treated severe COVID-19 and invasive aspergillosis in early hematopoietic cell transplantation setting

Manuela Spadea  1 , Francesca Carraro  1 , Francesco Saglio  1 , Elena Vassallo  1 , Rosanna Pessolano  1 , Massimo Berger  1 , Carlo Scolfaro  2 , Sergio Grassitelli  3 , Franca Fagioli  1
Affiliations
Case Reports

Successfully treated severe COVID-19 and invasive aspergillosis in early hematopoietic cell transplantation setting

Manuela Spadea et al. Transpl Infect Dis. 2021 Apr.
No abstract available

Keywords: COVID-19 management; hematopoietic cell transplantation; immune suppressed patients; invasive aspergillosis co-infection; ruxolitinib; severe COVID-19.

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Conflict of interest statement

The authors of this manuscript have no conflicts of interest to disclose as described by the Transplant Infectious disease journal.

Figures

Figure 1
Figure 1
Chest CT scan evolution from SARS‐CoV‐2 diagnosis (day + 27) to resolution of symptoms (day + 75). (A‐C) Several ground‐glass opacities mainly distributed in peripheral and juxta pleural bilateral lungs and diffuse consolidative lesions in the left lung. (B‐D) Important improvement of described lesions with reduction of ground‐glass opacities and consolidative lesions
Figure 2
Figure 2
Laboratory results and their correlation with clinical picture and therapeutic approach. All data are normalized for improving visualization; procalcitonin (PCT) values are then scaled to preserve proportions wrt. the other quantities. Normal values considered as follows: C‐reactive protein (CRP) < 5 mg/L, procalcitonin (PCT) < 2 ng/mL, ferritin < 110 ng/mL, D‐dimer < 500 ng/mL, interleukin‐6 (IL‐6) < 30 pg/mL. To be noted: ferritin did not return to the normal values, albeit our patient presented higher ferritin levels even before transplant (ferritin 3000 pg/mL), as frequent in HCT patients
See this image and copyright information in PMC

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