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. 2021 Feb 2;25(1):109-114.
doi: 10.5935/1518-0557.20200060.

Which ovarian reserve marker relates to embryo quality on day 3 and blastocyst; age, AFC, AMH?

Juliano Brum Scheffer  1 , Rafaela Friche de Carvalho  1 , Ana Paula de Souza Aguiar  1 , Iole Joana Moreira Machado  1 , Juliana Baumgratz Franca  1 , Daniel Mendez Lozano  2 , Renato Fanchin  3
Affiliations

Which ovarian reserve marker relates to embryo quality on day 3 and blastocyst; age, AFC, AMH?

Juliano Brum Scheffer et al. JBRA Assist Reprod. .

Abstract

Objective: The aim of the present prospective study was to evaluate which ovarian reserve marker would be more reliable as the quality of the A + B embryos (day 3 and blastocyst).

Methods: We ran a prospective study with 124 infertile women, aged 24-48 years, from 2017 to 2018. The patients were divided into 3 groups according to age and the subgroups were compared for AMH, AFC, number of A+B embryos. New division of the 3 groups was performed based on the AMH, and the subgroups were compared for age, AFC and number of A+B embryos. Finally, we divided the patients into 3 groups, based on the AFC, and we compared the subgroups for age, AMH and number of A+B embryos. P<0.05 was considered statistically significant.

Results: When the 124 patients were divided according to age, we found a significant fall in an A+B embryo quality (day3; blastocyst) after 35 years (p<0.038; p<0.035), and more severely after 37 years (p<0.032; p<0.027). When the 124 patients were divided according to AMH, there was a significant fall in A+B embryo quality (day 3; blastocyst), with AMH<1ng/ml (p<0.023; p<0.021). When the 124 patients were divided according to AFC, there was a significant fall in A+B embryo quality (day 3; blastocyst) with AFC<7 (p<0.025; p<0.023). These markers had significant associations with embryo quality (p<0.005).

Conclusion: Age, AFC and AMH have significant associations with A +B embryo quality on day 3 and blastocyst.

Keywords: AMH; age; antral follicle count; embryo quality; ovarian reserve.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare that there are no conflicts of interest.

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