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Review
. 2020 Sep 18;25(18):4282.
doi: 10.3390/molecules25184282.

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets

Wamidh H Talib  1 , Ahmad Riyad Alsayed  1 , Faten Farhan  1 , Lina T Al Kury  2
Affiliations
Review

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets

Wamidh H Talib et al. Molecules. .

Abstract

Resveratrol (3,4',5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tumor microenvironment. These players include blood and lymphatic vessels, infiltrating immune cells, stromal fibroblasts and the extracellular matrix. Targeting tumor microenvironment components is a promising strategy in cancer therapy. Resveratrol with its diverse biological activities has the capacity to target tumor microenvironment by manipulating the function of many components surrounding cancer cells. This review summarizes the targets of resveratrol in tumor microenvironment and the mechanisms involved in this targeting. Studies discussed in this review will participate in building a solid ground for researchers to have more insight into the mechanism of action of resveratrol in tumor microenvironment.

Keywords: anti-cancer; natural products; phytotherapy; resveratrol; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Resveratrol chemical structure in cis (A) and trans (B) isoforms. Trans is the biologically active form. Created using Biorender software.
Figure 2
Figure 2
Tumor microenvironment. Various host cells and proteins work together to support cancer cell survival and progression. Created using Biorender software.
See this image and copyright information in PMC

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