Review

. 2020 Sep 20;10(9):377.

doi: 10.3390/metabo10090377.

Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

Muhammad Shahid¹, Jayoung Kim^{1

2

3

4}

Affiliations

¹ Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Davis 5071, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
² Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
³ Department of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA.
⁴ Department of Urology, Ga Cheon University College of Medicine, Incheon 461-701, Korea.

PMID: 32962184
PMCID: PMC7570125
DOI: 10.3390/metabo10090377

Review

Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

Muhammad Shahid et al. Metabolites. 2020.

. 2020 Sep 20;10(9):377.

doi: 10.3390/metabo10090377.

Authors

Muhammad Shahid¹, Jayoung Kim^{1

2

3

4}

Affiliations

¹ Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Davis 5071, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
² Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
³ Department of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA.
⁴ Department of Urology, Ga Cheon University College of Medicine, Incheon 461-701, Korea.

PMID: 32962184
PMCID: PMC7570125
DOI: 10.3390/metabo10090377

Abstract

Cancer-related cognitive impairment (CRCI) is a significant comorbidity for cancer patients and survivors. Physical activity (PA) has been found to be a strong gene modulator that can induce structural and functional changes in the brain. PA and exercise reduce the risk of cancer development and progression and has been shown to help in overcoming post-treatment syndromes. Exercise plays a role in controlling cancer progression through direct effects on cancer metabolism. In this review, we highlight several priorities for improving studies on CRCI in patients and its underlying potential metabolic mechanisms.

Keywords: cancer-related cognitive impairment; metabolism; metabolomics profiling; therapeutic exercise intervention.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Jongsiriyanyong S., Limpawattana P. Mild Cognitive Impairment in Clinical Practice: A Review Article. Am. J. Alzheimers Dis. Other Demen. 2018;33:500–507. doi: 10.1177/1533317518791401. - DOI - PMC - PubMed
1. Robb C., Boulware D., Overcash J., Extermann M. Patterns of care and survival in cancer patients with cognitive impairment. Crit Rev. Oncol. Hematol. 2010;74:218–224. doi: 10.1016/j.critrevonc.2009.07.002. - DOI - PubMed
1. Barrios H., Narciso S., Guerreiro M., Maroco J., Logsdon R., de Mendonca A. Quality of life in patients with mild cognitive impairment. Aging Ment. Health. 2013;17:287–292. doi: 10.1080/13607863.2012.747083. - DOI - PubMed
1. Cheng Y.W., Chen T.F., Chiu M.J. From mild cognitive impairment to subjective cognitive decline: Conceptual and methodological evolution. Neuropsychiatr. Dis. Treat. 2017;13:491–498. doi: 10.2147/NDT.S123428. - DOI - PMC - PubMed
1. Valenzuela M., Sachdev P., Brodaty H. Reader response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018;91:372. doi: 10.1212/WNL.0000000000006039. - DOI - PubMed

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Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

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Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

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