Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2
- PMID: 32962613
- DOI: 10.2174/1568026620666200922112300
Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2
Abstract
The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a Receptor-binding Domain (RBD) that mediates the binding to host cell receptor, Angiotensin Converting Enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of Convalescent Plasma (CP) therapy to treat COVID-19 is also discussed.
Keywords: 2019-CoV-2; Anti-COVID-19 drugs; Antibodies; COVID-19; Convalescent plasma (CP) therapy; Epitopes; Vaccines.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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