Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep 22;20(1):252.
doi: 10.1186/s12890-020-01292-7.

Pulmonary tuberculosis presenting secondary organizing pneumonia with organized polypoid granulation tissue: case series and review of the literature

Eun Jin Kim  1 , Kyung Chan Kim  2
Affiliations
Review

Pulmonary tuberculosis presenting secondary organizing pneumonia with organized polypoid granulation tissue: case series and review of the literature

Eun Jin Kim et al. BMC Pulm Med. .

Erratum in

Abstract

Background: Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it has not been reported as a sequela of disseminated tuberculosis.

Methods: From January 2016 to December 2018, we identified six cases of tuberculosis-associated SOP in which Mycobacterium tuberculosis was revealed by microbiological examination; one of the cases was miliary tuberculosis.

Results: Of the six cases, 17% were positive for acid fast bacillus (AFB) stain, but 100% were positive for M. tuberculosis polymerase chain reaction (MTB PCR) and AFB culture. In all cases, transbronchial lung biopsy was performed and organizing pneumonia was confirmed pathologically. All survived after treatment with anti-tuberculosis therapy.

Conclusions: Pulmonary tuberculosis, which shows OP in lung biopsy, is diagnosed through MTB PCR and AFB culture, and the prognosis is thought to be good.

Keywords: Organizing pneumonia; Transbronchial lung biopsy; Tuberculosis.

PubMed Disclaimer

Conflict of interest statement

All authors listed above have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Chest computed tomography (CT) scan features of all six cases. a Case 1. Consolidation in both upper lobes and pleural effusion. Transbronchial lung biopsy (TBLB) was performed in the left upper lobe. b Case 2. Consolidation in the left lower lobe, which was subjected to TBLB. c Case 3. A thick-walled cavity is present in the right upper lobe, which was subjected to TBLB. d Case 4. Consolidation in the right lower and left lower lobes. TBLB was performed in the right lower lobe. e Case 5. Multiple nodules with patchy consolidation in both lungs. TBLB was performed in the right middle lobe. f Case 6. A solitary pulmonary nodule in the right upper lobe, which was subjected to TBLB
Fig. 2
Fig. 2
Lung pathologic features of all six cases. There were organizing polypoid granulation tissue plugs within alveolar ducts and terminal bronchioles. a Case 1, b Case 2, c Case 3, d Case 4, f Case 6. H & E stain, X 100. e Case 5. X200
Fig. 3
Fig. 3
Pre-treatment and post-treatment chest images of all six cases. a Case 1, b Case 2, c Case 3, d Case 4, e Case 5, f Case 6. In each case, ‘-Pre’ means before treatment and ‘-Post’ means after treatment. ‘E-2mo Tx’ means chest X ray at 2mo of treatment in case 5
See this image and copyright information in PMC

References

    1. European RS, Society AT. American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS executive committee, June 2001. Am J Respir Crit Care Med. 2002;165(2):277. doi: 10.1164/ajrccm.165.2.ats01. - DOI - PubMed
    1. Epler GR, Colby TV, McLoud TC, Carrington CB, Gaensler EA. Bronchiolitis obliterans organizing pneumonia. N Engl J Med. 1985;312(3):152–158. doi: 10.1056/NEJM198501173120304. - DOI - PubMed
    1. Epler GR. Bronchiolitis obliterans organizing pneumonia, 25 years: a variety of causes, but what are the treatment options? Expert Rev Respir Med. 2011;5(3):353–361. doi: 10.1586/ers.11.19. - DOI - PubMed
    1. Cordier J. Cryptogenic organising pneumonia. Eur Respir J. 2006;28(2):422. doi: 10.1183/09031936.06.00013505. - DOI - PubMed
    1. Drakopanagiotakis F, Polychronopoulos V, Judson MA. Organizing pneumonia. Am J Med Sci. 2008;335(1):34–39. doi: 10.1097/MAJ.0b013e31815d829d. - DOI - PubMed

Substances

LinkOut - more resources