Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov;16(11):597-598.
doi: 10.1038/s41582-020-00414-3.

The search for Alzheimer disease therapeutics - same targets, better trials?

Michael S Rafii  1 , Paul S Aisen  2
Affiliations
Review

The search for Alzheimer disease therapeutics - same targets, better trials?

Michael S Rafii et al. Nat Rev Neurol. 2020 Nov.
No abstract available

PubMed Disclaimer

References

    1. Selkoe, D. J. & Hardy, J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol. Med. 8, 595–608 (2016). - PubMed - PMC
    1. Cummings, J. L., Morstorf, T. & Zhong, K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res. Ther. 6, 37–43 (2014). - PubMed - PMC
    1. Knopman, D. S. Lowering of amyloid-β by β-secretase inhibitors — some informative failures. N. Engl. J. Med. 380, 1476–1478 (2019). - PubMed
    1. Donohue, M. C. et al. Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons. JAMA 317, 2305–2316 (2017). - PubMed - PMC
    1. Klein, G. et al. Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis. Alzheimers Res. Ther. 11, 101 (2019). - PubMed - PMC

MeSH terms

Substances

LinkOut - more resources