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. 2020 Oct 2;22(19):7635-7639.
doi: 10.1021/acs.orglett.0c02832. Epub 2020 Sep 23.

NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones

Di Meng  1   2 , Yangxi Xie  3 , Qiupeng Peng  3 , Jian Wang  1   3
Affiliations

NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones

Di Meng et al. Org Lett. .

Abstract

The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities.

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