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Comparative Study
. 2021 Apr;48(4):486-494.
doi: 10.1111/cup.13882. Epub 2020 Oct 29.

Comparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study

Dinesha Ruwanthi Jayasinghe  1 , Karuna Dissanayake  2 , Mannikawadumesthri Vipula Chandu de Silva  1
Affiliations
Comparative Study

Comparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study

Dinesha Ruwanthi Jayasinghe et al. J Cutan Pathol. 2021 Apr.

Abstract

Background: Mycosis fungoides (MF), the commonest primary cutaneous T-cell lymphoma, has classic and variant types which include hypopigmented MF (HMF). Previous studies have identified distinct clinicopathological profiles in HMF. This study aims to objectively compare the clinicopathological features of HMF with non-HMF lesions in order to characterize salient features of HMF.

Methods: This cross-sectional, retrospective study analyzed biopsy specimens of 87 patients with MF. HMF and non-HMF groups were compared using clinical data, immunophenotypic features and scores given for six histopathological features: dermal infiltrate, basilar and superficially extending epidermotropism, Pautrier microabscesses and dermal and epidermotropic lymphocytic atypia.

Results: Seventy-six patients had HMF. Presentation in females (59.21%; p = .04) and patch stage (88.16%; p = .01) in HMF were significant, and HMF presented at a younger mean age when compared to non-HMF. Both groups had equal intensity of epidermotropism, with HMF showing milder dermal infiltrates and significantly less dermal atypia. Pautrier microabscesses were significantly commoner in non-HMF (LR 10.76; p < .01). 94.74% of HMF were CD4-/CD8+.

Conclusion: HMF presents at a lower age and earlier stage with female predominance compared to non-HMF. Because of milder dermal infiltrates, less dermal atypia, and Pautrier microabscesses, the diagnosis of HMF requires correlation with clinical features and careful assessment of epidermotropic cells.

Keywords: CD8-positive mycosis fungoides; cutaneous lymphoma; hypopigmented mycosis fungoides.

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REFERENCES

    1. Samimi S, Rook AH, Kim EJ. Update on epidemiology of cutaneous T-cell lymphoma. Curr Dermatol Rep. 2013;2(1):35-41. https://doi.org/10.1007/s13671-012-0038-2.
    1. Zindanci I. Clinicopathological evaluation and outcome of mycosis fungoides. Sci J Clin Med. 2014;3(4):65-69. https://doi.org/10.11648/j.sjcm.20140304.12.
    1. Cerroni L, Sander CA, Smoller BR, Willemze R. Mycosis fungoides. In: Elder DE, Massi D, Willemze R, Scolyer R, eds. WHO Classification of Skin Tumours. 4th ed. International Agency for Research on Cancer; 2018:226-230.
    1. Cerroni L, Hodak E, Kempf W, Pincus LB, Smoller BR, Willemze R. Variants of mycosis fungoides. In: Elder DE, Massi D, Willemze R, Scolyer R, eds. WHO Classification of Skin Tumours. 4th ed. International Agency for Research on Cancer; 2018:231-233.
    1. Furlan FC, Sanches JA. Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology. An Bras Dermatol. 2013;88(6):954-960. https://doi.org/10.1590/abd1806-4841.20132336.

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