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Comment
. 2020 Sep;16(9):e9965.
doi: 10.15252/msb.20209965.

Implications of initial physiological conditions for bacterial adaptation to changing environments

Matthias Heinemann  1 , Markus Basan  2   3 , Uwe Sauer  2
Affiliations
Comment

Implications of initial physiological conditions for bacterial adaptation to changing environments

Matthias Heinemann et al. Mol Syst Biol. 2020 Sep.

Abstract

This piece discusses how the different observations of two independent studies (Kotte et al, 2014; Basan et al, 2020), regarding population-level heterogeneity and lag times during diauxic shift, can be largely explained by different experimental protocols.

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Figures

Figure 1
Figure 1
Schematic of phenotypic states and relevant molecular challenges for the diauxic shift from growth on glucose to acetate of Escherichia coli.
See this image and copyright information in PMC

Comment on

References

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    1. Kotte O, Volkmer B, Radzikowski JL, Heinemann M (2014) Phenotypic bistability in Escherichia coli's central carbon metabolism. Mol Syst Biol 10: 736 - PMC - PubMed
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