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Book

Cancer Antigen 125

Tanmay Gandhi  1 , Muhammad Zubair  2 , Harshil Bhatt  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Cancer Antigen 125

Tanmay Gandhi et al.
Free Books & Documents

Excerpt

Cancer antigen 125 (CA125) is an antigenic tumor marker expressed by epithelial ovarian neoplasms and cells lining various organs such as the endometrium, fallopian tubes, pleura, peritoneum, and pericardium. CA125 is used as one of the serological tests in cases when an ovarian neoplasm is suspected and for monitoring patients who have already been diagnosed with epithelial ovarian cancers. However, due to its low sensitivity, the test has limited use in diagnosing early ovarian cancer. The specificity is particularly low in premenopausal women; thus, it is most useful in postmenopausal women.

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Conflict of interest statement

Disclosure: Tanmay Gandhi declares no relevant financial relationships with ineligible companies.

Disclosure: Muhammad Zubair declares no relevant financial relationships with ineligible companies.

Disclosure: Harshil Bhatt declares no relevant financial relationships with ineligible companies.

References

    1. Jacobs I, Bast RC. The CA 125 tumour-associated antigen: a review of the literature. Hum Reprod. 1989 Jan;4(1):1-12. - PubMed
    1. Scholler N, Urban N. CA125 in ovarian cancer. Biomark Med. 2007 Dec;1(4):513-23. - PMC - PubMed
    1. Zhang R, Siu MKY, Ngan HYS, Chan KKL. Molecular Biomarkers for the Early Detection of Ovarian Cancer. Int J Mol Sci. 2022 Oct 10;23(19) - PMC - PubMed
    1. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology. Practice Bulletin No. 174: Evaluation and Management of Adnexal Masses. Obstet Gynecol. 2016 Nov;128(5):e210-e226. - PubMed
    1. Charkhchi P, Cybulski C, Gronwald J, Wong FO, Narod SA, Akbari MR. CA125 and Ovarian Cancer: A Comprehensive Review. Cancers (Basel) 2020 Dec 11;12(12) - PMC - PubMed

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