Lymphocytic Hypophysitis
- PMID: 32965926
- Bookshelf ID: NBK562255
Lymphocytic Hypophysitis
Excerpt
Lymphocytic hypophysitis is a rare pathology of the pituitary gland which presents with features of hypopituitarism due to inflammation of the pituitary gland and/or a sellar mass lesion. It consists of the infiltration of the pituitary gland by T and B lymphocytes. It is an autoimmune condition and is the most frequent histopathological subtype of primary hypophysitis. Endocrine symptoms are due to pituitary dysfunction and can include central diabetes insipidus, anterior pituitary hormone deficiencies, and hyperprolactinemia, or hyperprolactinemia. Given that it is relatively rare, diagnosis and treatment can be challenging.
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References
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- Nanda A, Savardekar AR, Patra DP. Diagnosis and management of lymphocytic hypophysitis: A synopsis on current perspective. Neurol India. 2018 Mar-Apr;66(2):405-406. - PubMed
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- Joshi MN, Whitelaw BC, Carroll PV. MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment. Eur J Endocrinol. 2018 Sep;179(3):R151-R163. - PubMed
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