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Review

How Do Tumor-Treating Fields Work?

Kristen W. Carlson  1 , Jack A. Tuszynski  2 , Socrates Dokos  3 , Nirmal Paudel  4 , Thomas Dreeben  5 , Ze’ev Bomzon  6
Sergey N. Makarov  1 , Gregory M. Noetscher  1 , Aapo Nummenmaa  2
, editors.
In: Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting [Internet]. Cham (CH): Springer; 2021.
.
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Review

How Do Tumor-Treating Fields Work?

Kristen W. Carlson et al.
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Excerpt

Since approved by the FDA for the treatment of glioblastoma brain cancer in 2015, tumor-treating fields (TTFields) have rapidly become the fourth modality to treat cancer, along with surgery, chemotherapy, and radiation [1]. TTFields are now in clinical trials for a variety of cancer types. While efficacy has been proven in the clinic, the higher efficacy is demonstrated in vitro and in animal models, which indicates much greater clinical efficacy is possible. To attain the great promise of TTFields, uncovering the mechanisms of action (MoA) is necessary.

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References

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    1. Kirson, E. D., et al. (2007). Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proceedings of the National Academy of Sciences of the United States of America, 104, 10152–10157. - PMC - PubMed
    1. Giladi, M., et al. (2015). Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells. Scientific Reports, 5, 18046. - PMC - PubMed
    1. Gera, N., et al. (2015). Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit. PLoS One, 10, e0125269. - PMC - PubMed

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