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Comment
. 2020 Oct 5;219(10):e202009042.
doi: 10.1083/jcb.202009042.

Nesprin-2G tension fine-tunes Wnt/β-catenin signaling

Cara J Gottardi  1   2 , G W Gant Luxton  3
Affiliations
Comment

Nesprin-2G tension fine-tunes Wnt/β-catenin signaling

Cara J Gottardi et al. J Cell Biol. .

Abstract

How LINC complexes mediate nuclear mechanotransduction remains unclear. In this issue, Déjardin, Carollo, et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201908036) show that the LINC complex protein nesprin-2G is a mechanosensor of epithelial-mesenchymal transitions (EMTs), recruiting α-catenin to the nucleus to attenuate Wnt/β-catenin signaling.

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Figures

Figure 1.
Figure 1.
A Biorender.com-generated illustration showing that mini-nesprin-2G at the NE undergoes cytoskeleton-dependent extension under partial, but not complete, EMT. This impairs its ability to recruit α-catenin (α-cat) and thus limit β-catenin (β-cat) signaling through end point mediators like the transcription factor T cell factor (TCF).
See this image and copyright information in PMC

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References

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