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Review
. 2020 Sep 21;25(18):4320.
doi: 10.3390/molecules25184320.

The Effects of Flavonoids in Cardiovascular Diseases

Lorena Ciumărnean  1 , Mircea Vasile Milaciu  1 , Octavia Runcan  2 , Ștefan Cristian Vesa  3 , Andreea Liana Răchișan  4 , Vasile Negrean  1 , Mirela-Georgiana Perné  1 , Valer Ioan Donca  5 , Teodora-Gabriela Alexescu  1 , Ioana Para  1 , Gabriela Dogaru  6
Affiliations
Review

The Effects of Flavonoids in Cardiovascular Diseases

Lorena Ciumărnean et al. Molecules. .

Abstract

Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids' potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.

Keywords: cardiovascular disease; flavonoids; polyphenols.

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Conflict of interest statement

The authors declare no conflict of interest.

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