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Meta-Analysis
. 2020 Sep 21;17(18):6889.
doi: 10.3390/ijerph17186889.

Quality of Life Changes in Acute Coronary Syndromes Patients: A Systematic Review and Meta-Analysis

Billingsley Kaambwa  1 , Hailay Abrha Gesesew  1   2 , Matthew Horsfall  1 , Derek Chew  1
Affiliations
Meta-Analysis

Quality of Life Changes in Acute Coronary Syndromes Patients: A Systematic Review and Meta-Analysis

Billingsley Kaambwa et al. Int J Environ Res Public Health. .

Abstract

There is little up-to-date evidence about changes in quality of life following treatment for acute coronary syndrome (ACS) patients. The main aim of this review was to assess the changes in QoL in ACS patients after treatment. We undertook a systematic review and meta-analysis of quantitative studies. The search included studies that described the change of QoL of ACS patients after receiving treatment options such as percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical therapy (MT). We synthesized findings using content analysis and pooled the estimates using meta-analysis. We used the PRISMA guidelines to select and appraise the studies and report the findings. Twenty-nine (29) articles were included in the review. We found a significant improvement of QoL in ACS patients after receiving treatment. Particularly, the meta-analytic association found that the mean QoL of patients diagnosed with ACS was higher after receiving treatment compared to baseline (overall pooled mean difference = 31.88; 95% CI = 31.64-52.11, I2 = 98) with patients on PCI having slightly lower QoL gains (pooled mean difference = 30.22; 95% CI = 29.9-30.53, I2 = 0%) compared to those on CABG (pooled mean difference = 34.01; 95% CI = 33.66-34.37, I2 = 0%). The review confirmed that QoL of ACS patients improved after receiving treatment therapies although varied by the treatment options and patients' preferences. This suggests the need to perform further study on the QoL, patient preferences and physicians' decision to prescription of treatment options.

Keywords: acute coronary syndrome; coronary artery bypass grafting; percutaneous coronary intervention; physician therapy; quality of life; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure A1
Figure A1
JBI Critical Appraisal Checklist for Descriptive/Case Series.
Figure A2
Figure A2
JBI Critical Appraisal Checklist for Comparable Cohort/Case Control.
Figure A3
Figure A3
JBI Critical Appraisal Checklist for Randomised Cohort/Pseudo-randomised Trial.
Figure A4
Figure A4
JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses.
Figure A5
Figure A5
JBI Data Extraction Form for Experimental/Observational Studies.
Figure 1
Figure 1
Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flowchart for identification and selection of studies for inclusion in the systematic search, 2019. * One article assessed both outcomes.
Figure 2
Figure 2
Forest plot of meta-analytic association between QoL and ACS treatments, 2019.
See this image and copyright information in PMC

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