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. 2020 Sep;48(9):300060520951649.
doi: 10.1177/0300060520951649.

CD14, CD163, and CCR1 are involved in heart and blood communication in ischemic cardiac diseases

Chengcong Chen  1 , Hong Peng  2 , Yongmei Zeng  1 , Guoqing Dong  1
Affiliations

CD14, CD163, and CCR1 are involved in heart and blood communication in ischemic cardiac diseases

Chengcong Chen et al. J Int Med Res. 2020 Sep.

Abstract

Objective: Cardiac diseases lead to heart failure (HF), but the progression can take several years. Using blood samples to monitor changes in the heart before clinical symptoms begin may help to improve patient management.

Methods: Microarray data GSE42955 and GSE9128 were used as study datasets and GSE16499, GSE57338, and GSE59867 were used as validation groups. The "limma" package from R Language was used to identify differentially expressed genes. Functional enrichment analyses of gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways were performed using Database for Annotation, Visualization and Integrated Discovery. We also investigated the correlation between the heart and blood using the mRNA expression level.

Results: Three hub genes, CD14, CD163, and CCR1, were identified. Functional enrichment analyses showed their involvement in the immune response and in the inflammatory response, which are the critical biochemical processes in ischemic HF. The mRNA expression level further demonstrated that a special model may exist to help to predict the mRNA level in the heart based on that in blood.

Conclusions: Our study identified three biomarkers that can connect the heart and blood in ischemic heart diseases, which may be a new approach to help better manage ischemic cardiac disease patients.

Keywords: Heart and blood communication; ST-elevation myocardial infarction; biomarker; differentially expressed genes; heart disease; heart failure; ischemic cardiomyopathy.

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Figures

Figure 1.
Figure 1.
PPI network of 12 shared genes. Eleven of 12 genes were enriched. PPI, protein–protein interaction.
Figure 2.
Figure 2.
PPI network of heart tissue (GSE42955), which was simplified into TOP50 on the basis of the connectivity degree. PPI, protein–protein interaction.
Figure 3.
Figure 3.
PPI network of PBMC (GSE9128), simplified into TOP50 on the basis of the connectivity degree. PPI, protein–protein interaction; PBMC, peripheral blood mononuclear cells.
Figure 4.
Figure 4.
mRNA level of three hub genes. The data has gone through log2 management.
See this image and copyright information in PMC

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