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. 2020 Sep-Oct;36(6):1334-1338.
doi: 10.12669/pjms.36.6.2945.

Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis

Zheng Zhang  1 , Ming-Hua Xu  2 , Feng-Ju Wei  3 , Li-Na Shang  4
Affiliations

Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis

Zheng Zhang et al. Pak J Med Sci. 2020 Sep-Oct.

Abstract

Objective: To evaluate the efficacy of atorvastatin combined with febuxostat in the treatment of gout patients with carotid atherosclerosis and to observe the effects on serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP) levels, carotid plaques, and the adverse reactions.

Methods: Seventy patients with gout and carotid atherosclerosis admitted to Affiliated Hospital of Hebei University from January 2014 to June 2017 were randomly divided into a treatment group and a control group. The treatment group received oral febuxostat 40 mg/day combined with atorvastatin 40 mg/day. The control group was given 40 mg/day febuxostat combined with 20 mg/day atorvastatin for 90 days. The effects of treatment on TNF-α, IL-1β, and CRP levels and carotid plaques of the patients were observed.

Results: After 90 days of treatment, serum TNF-α, IL-1β, and CRP levels, as well as HUA and total cholesterol (TC), decreased in both groups after treatment. There were significant differences observed (p < 0.05). The carotid artery plaques in the two groups were significantly smaller after treatment (P<0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05).

Conclusion: Double doses of atorvastatin combined with febuxostat can effectively reduce uric acid to improve the inflammatory state in patients and reduce carotid plaques without increasing the incidence of adverse reactions.

Keywords: Atorvastatin; Carotid atherosclerosis; Febuxostat; Gout.

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Conflict of interest statement

Declaration of conflicts of interest: None.

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