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Review
. 2021 Jan;41(1):175-189.
doi: 10.1002/jat.4072. Epub 2020 Sep 24.

A new look at 9-substituted acridines with various biological activities

Maria Kozurkova  1   2 , Danica Sabolova  1 , Pavol Kristian  3
Affiliations
Review

A new look at 9-substituted acridines with various biological activities

Maria Kozurkova et al. J Appl Toxicol. 2021 Jan.

Abstract

Heterocycles have long been the focus of intensive study in attempts to develop novel therapeutic compounds, and acridine, a polynuclear nitrogen molecule containing a heterocycle, has attracted a considerable amount of scientific attention. Acridine derivatives have been studied in detail and have been found to possess multitarget properties, which inhibit topoisomerase enzymes that regulate topological changes in DNA and interfere with the essential biological function of DNA. This article describes some recent advancements in the field of new 9-substituted acridine heterocyclic agents and describes both the structure and the structure-activity relationship of the most promising molecules. The article will also present the IC50 values of the novel derivatives against various human cancer cell lines. The mini review also investigates the topoisomerase inhibition and antibacterial and antimalarial activity of these polycyclic aromatic derivatives.

Keywords: 9-substituted acridine; antibacterial; anticancer; antimalarial; topoisomerase II inhibition activity.

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References

REFERENCES

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