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Review
. 2021 Feb;21(2):460-474.
doi: 10.1111/ajt.16318. Epub 2020 Oct 23.

Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement

David P Al-Adra  1 , Laura Hammel  2 , John Roberts  3 , E Steve Woodle  4 , Deborah Levine  5 , Didier Mandelbrot  6 , Elizabeth Verna  7 , Jayme Locke  8 , Jonathan D'Cunha  9 , Maryjane Farr  7 , Deirdre Sawinski  10 , Piyush K Agarwal  11 , Jennifer Plichta  12 , Sandhya Pruthi  13 , Deborah Farr  14 , Richard Carvajal  7 , John Walker  15 , Fiona Zwald  16 , Thomas Habermann  17 , Morie Gertz  17 , Philip Bierman  18 , Don S Dizon  19 , Carrie Langstraat  20 , Talal Al-Qaoud  1 , Scott Eggener  11 , John P Richgels  11 , George J Chang  21 , Cristina Geltzeiler  1 , Gonzalo Sapisochin  22 , Rocco Ricciardi  23 , Alexander S Krupnick  24 , Cassie Kennedy  13 , Nisha Mohindra  25 , David P Foley  1 , Kymberly D Watt  13
Affiliations
Review

Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement

David P Al-Adra et al. Am J Transplant. 2021 Feb.

Abstract

Patients undergoing evaluation for solid organ transplantation (SOT) often have a history of malignancy. Although the cancer has been treated in these patients, the benefits of transplantation need to be balanced against the risk of tumor recurrence, especially in the setting of immunosuppression. Prior guidelines of when to transplant patients with a prior treated malignancy do not take in to account current staging, disease biology, or advances in cancer treatments. To develop contemporary recommendations, the American Society of Transplantation held a consensus workshop to perform a comprehensive review of current literature regarding cancer therapies, cancer stage-specific prognosis, the kinetics of cancer recurrence, and the limited data on the effects of immunosuppression on cancer-specific outcomes. This document contains prognosis based on contemporary treatment and transplant recommendations for breast, colorectal, anal, urological, gynecological, and nonsmall cell lung cancers. This conference and consensus documents aim to provide recommendations to assist in the evaluation of patients for SOT given a history of a pretransplant malignancy.

Keywords: cancer / malignancy / neoplasia; clinical research / practice; editorial / personal viewpoint; organ transplantation in general; patient safety; recipient selection.

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Conflict of interest statement

Disclosure

The authors of this manuscript have no conflicts of interest to disclose as described by The American Journal of Transplantation.

Figures

Figure 1.
Figure 1.
Potential factors to Consider When Evaluating a Patient with a PTM for Transplantation.
See this image and copyright information in PMC

Comment in

References

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