Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr;48(2):145-156.
doi: 10.1111/iji.12514. Epub 2020 Sep 24.

Human neutrophil antigens: Nature, clinical significance and detection

Tom Browne  1 , Rebecca J Dearman  2 , Anthony Poles  1
Affiliations
Review

Human neutrophil antigens: Nature, clinical significance and detection

Tom Browne et al. Int J Immunogenet. 2021 Apr.

Abstract

Granulocytes are an essential part of both the innate and adaptive immune systems. Human neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that are mostly expressed on human granulocytes. Antibodies that recognize these epitopes have been associated with neutropenia, transfusion complications, haematopoietic stem cell transplant nonengraftment and renal transplant rejection. Currently, there are fourteen recognized HNA alleles across five antigen systems (HNA-1 through HNA-5), the molecular basis of which are located on the genes FCGR3B, CD177, SLC44A2, ITGAM and ITGAL, respectively. Elucidation of the associated genes has permitted the development of testing strategies for HNA typing and aided understanding of the associated epitopes. This review will outline the associated clinical conditions that require HNA investigation and how these are performed in specialized laboratories. Investigations provided are both reactive for patients with a variety of existing or suspected neutropenias and proactive in the testing of blood component donors in order to reduce the potential risk to patients who require transfusion.

Keywords: FCGR3B; ITGAL; SLC44A2; CD11a/CD18; CD11b/CD18 ITGAM; CD16b; CD177; CLT-2; GAT; GIFT; HNA; MAIGA; granulocyte; human neutrophil antigen; rHNA.

PubMed Disclaimer

References

REFERENCES

    1. Akhtari, M., Curtis, B., & Waller, E. K. (2009). Autoimmune neutropenia in adults. Autoimmunity Reviews, 9, 62-66. https://doi.org/10.1016/j.autrev.2009.03.006
    1. Arnaout, M. A. (2016). Biology and structure of leukocyte beta 2 integrins and their role in inflammation. F1000 Research, 5. https://doi.org/10.12688/f1000research.9415.1
    1. Audrain, M., Martin, J., Fromont, P., Prie, N., Thomas, C., & Muller, E. J. (2011). Autoimmune neutropenia in children: Analysis of 116 cases. Pediatric Allergy and Immunology, 22(5), 494-496. https://doi.org/10.1111/j.1399-3038.2010.01117.x
    1. Bayat, B. (2019). Molecular basis of human neutrophil antigen 2 (HNA-2) expression. ISBT Science Series, https://doi.org/10.1111/voxs.12536
    1. Bayat, B., Bein, G., & Sachs, U. J. (2016). A sequence-specific polymerase chain reaction method for HNA-2 genotyping: Homozygous c.843A>T mutation predicts the absence of CD177. Transfusion, 56(8), 2127-2132. https://doi.org/10.1111/trf.13689

LinkOut - more resources