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Case Reports
. 2020 Oct;68(10):2288-2290.
doi: 10.4103/ijo.IJO_2185_19.

From an asymptomatic lesion to a vision-threatening condition: Congenital hypertrophy of the retinal pigment epithelium complicated by choroidal neovascular membrane

Raziye Donmez Gun  1 , Güzide Akcay  1 , Hatice Selen Kanar  1 , Şaban Şimşek  1
Affiliations
Case Reports

From an asymptomatic lesion to a vision-threatening condition: Congenital hypertrophy of the retinal pigment epithelium complicated by choroidal neovascular membrane

Raziye Donmez Gun et al. Indian J Ophthalmol. 2020 Oct.

Abstract

We reported a case of congenital hypertrophy of the retinal pigment epithelium (CHRPE) complicated by choroidal neovascular membrane (CNVM). A 41-year-old woman presented to our clinic with visual loss in the left eye. She was diagnosed as CHRPE complicated by a CNVM. The patient was treated with 2 consecutive monthly intravitreal aflibercept (IVA) injections. The best-corrected visual acuity (BCVA) improved and stabilized at 6/6. Subretinal fluid depending on CNVM resolved completely. CHRPE complicated by CNVM in the macular area is a rare condition and these cases can be treated with IVA therapy.

Keywords: Aflibercept; benign melanoma; choroidal neovascular membrane; congenital hypertrophy of the retinal pigment epithelium.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Color fundus photograph of the normal right eye and color fundus photograph of the left eye showing a single, flat, well demarcated, circular, black plaque (CHRPE). Lipid exudates, a small intraretinal hemorrhage near the upper margin of the lesion and a retinal thickened area corresponding to the foveal zone are seen
Figure 2
Figure 2
SD-OCT of the left eye showing flat hyper-reflective lesion with irregularly, slightly thickened RPE, moderate relative shadowing of the underlying choroid and replacement of the choroidal architecture with the CHRPE lesion. CNVM is seen above the RPE with SRF on both sides adjacent to the CNMV lesion
Figure 3
Figure 3
Red free image of the left eye showing hypoautofluorescence at the region of CHRPE lesion
Figure 4
Figure 4
(a) FFA of the left eye at 5.8 seconds. The CHRPE lesion is showing hypofluorescence. Dye leakage and early hyperfluorescence adjacent to the CHRPE plaque is seen. (b) FFA of the left eye at 5 minutes, 16 seconds. Increased hyperfluorescence and late retinal leakage consistent with a CNVM
Figure 5
Figure 5
SD-OCT of the left eye showing completely resolved SRF on both sides adjacent to the CNMV lesion
See this image and copyright information in PMC

References

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