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Review
. 2020 Sep 22;25(18):4343.
doi: 10.3390/molecules25184343.

The Lipidome Fingerprint of Longevity

Mariona Jové  1 , Natàlia Mota-Martorell  1 , Irene Pradas  1 , José Daniel Galo-Licona  1 , Meritxell Martín-Gari  1 , Èlia Obis  1 , Joaquim Sol  1 , Reinald Pamplona  1
Affiliations
Review

The Lipidome Fingerprint of Longevity

Mariona Jové et al. Molecules. .

Abstract

Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species-humans included-demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.

Keywords: fatty acids; lipidomics; longevity; membrane unsaturation; peroxidation index.

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Conflict of interest statement

The authors declare that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Specific lipidomic profiles at subcellular, tissue, and animal species level. (A) Specific lipidomic profile defines different subcellular components such as endoplasmic reticulum (ER), mitochondrial-associated membranes (MAM), and mitochondrion (MIT). (B) Specific lipidomic profile for rat tissues. Principal component analysis (PCA) representation of the lipidome of all the tissues in positive ionization. Modified with permission from [46]. (C) Specific plasma lipidomic profiles for mammalian species. PCA representation (positive ionization molecules) showing that plasma lipidomic profiles are species-specific. Modified with permission from [35]. (D) Human extreme longevity as model of healthy aging. PCA (positive ionization) revealed differences in adults, aged, and centenarian plasma lipidomic profiles. Modified with permission from [48].
Figure 2
Figure 2
Relationship between peroxidation index (PI) and longevity of skeletal muscle phospholipids for mammalians and birds, pointing out exceptionally long-lived animal species. Modified with permission from [28].
See this image and copyright information in PMC

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