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Meta-Analysis
. 2020 Sep 22;17(18):6936.
doi: 10.3390/ijerph17186936.

Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Alicia Saz-Lara  1 , Celia Álvarez-Bueno  1   2 , Vicente Martínez-Vizcaíno  1   3 , Blanca Notario-Pacheco  1 , Irene Sequí-Dominguez  1 , Iván Cavero-Redondo  1   2
Affiliations
Meta-Analysis

Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Alicia Saz-Lara et al. Int J Environ Res Public Health. .

Abstract

Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.

Keywords: advanced glycation end products; arterial stiffness; cardiovascular disease; carotid intima media thickness; pulse wave velocity; skin autofluorescence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart: Search strategy.
Figure 2
Figure 2
Forest plot including correlation between pulse wave velocity or carotid intima media thickness and skin autofluorescence.
Figure 3
Figure 3
Forest plot including correlation between pulse wave velocity or carotid intima media thickness and skin autofluorescence in diabetic patients.
See this image and copyright information in PMC

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