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Review
. 2020 Oct;59(5):102951.
doi: 10.1016/j.transci.2020.102951. Epub 2020 Sep 16.

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Maria Bianchi  1 , Nicoletta Orlando  1 , Caterina Giovanna Valentini  1 , Patrizia Papacci  2 , Giovanni Vento  2 , Luciana Teofili  3
Affiliations
Review

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Maria Bianchi et al. Transfus Apher Sci. 2020 Oct.

Abstract

Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.

Keywords: Bacterial infections; Cytomegalovirus; Hepatitis; Neonatal transfusion.

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Conflict of interest statement

The authors report no declarations of interest.

Figures

Fig. 1
Fig. 1
Study flow diagram.
See this image and copyright information in PMC

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