Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents
- PMID: 3297311
Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents
Abstract
Resistance to a variety of naturally occurring antitumour agents, including the anthracyclines, vinca alkaloids and actinomycin D, is associated with an outward transport system which limits intracellular drug accumulation to sublethal levels. A series of agents of unrelated structure, including calcium and calmodulin antagonists, local anaesthetics and detergents, can impair this outward transport system, and thereby promote cytotoxicity of these antitumour agents. These effects are not related to alterations in calcium fluxes, but appear to derive from membrane perturbations which also affect other transport systems. There are additional modes of drug resistance not based on transport alterations which are apparently unaffected by these second agents.
Similar articles
-
[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].Gan To Kagaku Ryoho. 1984 Mar;11(3 Pt 2):750-9. Gan To Kagaku Ryoho. 1984. PMID: 6585181 Japanese.
-
Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists.Cancer Res. 1986 Sep;46(9):4352-6. Cancer Res. 1986. PMID: 3460695
-
Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.Cancer Res. 1985 Apr;45(4):1687-91. Cancer Res. 1985. PMID: 3919944
-
Modes of resistance to anthracyclines and other natural products.Prog Clin Biol Res. 1986;223:81-93. Prog Clin Biol Res. 1986. PMID: 3543948 Review. No abstract available.
-
Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics.Cancer Treat Rep. 1983 Oct;67(10):889-94. Cancer Treat Rep. 1983. PMID: 6354436 Review.
Cited by
-
Occurrence of a multidrug-resistant phenotype in human lung xenografts.Br J Cancer. 1987 Oct;56(4):407-11. doi: 10.1038/bjc.1987.215. Br J Cancer. 1987. PMID: 3689658 Free PMC article.
-
Molecular mechanisms of drug resistance.Biochem J. 1990 Dec 1;272(2):281-95. doi: 10.1042/bj2720281. Biochem J. 1990. PMID: 1980062 Free PMC article. Review. No abstract available.
-
Chemoprotection of normal tissues by transfer of drug resistance genes.Cancer Metastasis Rev. 1996 Sep;15(3):365-83. doi: 10.1007/BF00046348. Cancer Metastasis Rev. 1996. PMID: 9034597 Review.
-
Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.Br J Cancer. 1990 Jul;62(1):85-8. doi: 10.1038/bjc.1990.234. Br J Cancer. 1990. PMID: 2390489 Free PMC article.
-
Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro.Cytotechnology. 1993;12(1-3):265-88. doi: 10.1007/BF00744668. Cytotechnology. 1993. PMID: 7765329 Review.