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Comment
. 2020 Aug 21:14:248.
doi: 10.3389/fncel.2020.00248. eCollection 2020.

Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway

Jenesis D Gayden  1   2 , Zachary Freyberg  2   3
Affiliations
Comment

Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway

Jenesis D Gayden et al. Front Cell Neurosci. .
No abstract available

Keywords: Wnt signaling; dopaminergic neurogenesis; ghrelin; neural stem cells; neuron differentiation; neuroregeneration.

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Figures

Figure 1
Figure 1
A model for Wnt-mediated neuronal regeneration. Degenerative disease processes lead to dopaminergic neuron loss, resulting in decreased synaptic D2R activity. This decrease in activity releases the inhibitory brake on Wnt3a production and increases Wnt3a levels, consequently stimulating neural stem cell proliferation and restoring cellular and synaptic dopamine levels. As DA levels rise, inhibitory D2R activity increases, which then diminishes levels of Wnt3a. Ghrelin compensates for this decrease by serving as a critical counterbalance and increasing Wnt3a expression in response. As a result, proliferation and regeneration of dopaminergic neurons is auto-regulated, thus preventing unchecked cell proliferation.
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References

    1. Berg D. A., Kirkham M., Wang H., Frisén J., Simon A. (2011). Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. Cell Stem Cell 8, 426–433. 10.1016/j.stem.2011.02.001 - DOI - PubMed
    1. Bonzano S., Bovetti S., Gendusa C., Peretto P., De Marchis S. (2016). Adult born olfactory bulb dopaminergic interneurons: molecular determinants and experience-dependent plasticity. Front. Neurosci. 10:189. 10.3389/fnins.2016.00189 - DOI - PMC - PubMed
    1. Gale E., Li M. (2008). Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells. Mol. Brain 1:8. 10.1186/1756-6606-1-8 - DOI - PMC - PubMed
    1. Gong B., Jiao L., Du X., Li Y., Bi M., Jiao Q., et al. (2020). Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through Wnt/β-catenin pathway. J. Cell. Physiol. 10.1002/jcp.29699. [Epub ahead of print]. - DOI - PubMed
    1. Han F., Konkalmatt P., Mokashi C., Kumar M., Zhang Y., Ko A., et al. (2019). Dopamine D2 receptor modulates Wnt expression and control of cell proliferation. Sci. Rep. 9:16861. 10.1038/s41598-019-52528-4 - DOI - PMC - PubMed

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