Commentary: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Alexandra Lindsey Zune Djomkam^{1

2}, Charles Ochieng' Olwal^{1

2}, Theodore Beyeme Sala³, Lily Paemka^{1

2}

Affiliations

¹ West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
² Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
³ Department of Urology, Laquintinie Hospital, Douala, Cameroon.

Comment

Alexandra Lindsey Zune Djomkam et al. Front Oncol. 2020.

. 2020 Aug 19:10:1448.

doi: 10.3389/fonc.2020.01448. eCollection 2020.

Alexandra Lindsey Zune Djomkam^{1

2}, Charles Ochieng' Olwal^{1

2}, Theodore Beyeme Sala³, Lily Paemka^{1

2}

¹ West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
² Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
³ Department of Urology, Laquintinie Hospital, Douala, Cameroon.

No abstract available

Keywords: ACE2; COVID-19; SARS-CoV-2; TMPRSS2; coronavirus; prostate cancer.

Comment on

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. Hoffmann M, et al. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. Cell. 2020. PMID: 32142651 Free PMC article.

1. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. (2020) 181:271–80. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed
1. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. (2020) 367:1444–8. 10.1126/science.abb2762 - DOI - PMC - PubMed
1. Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. (2020) 579:270–3. 10.1038/s41586-020-2012-7 - DOI - PMC - PubMed
1. Cheng H, Wang Y, Wang G. Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J Med Microbiol. (2020) 2020:1–5. 10.1002/jmv.25785 - DOI - PMC - PubMed
1. Sama I, Ravera A, Santema B, Goor H, Maaten J, Cleland J, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. (2020) 41:1810–7. 10.1093/eurheart/ehaa373 - DOI - PMC - PubMed