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. 2020 Oct:60:103015.
doi: 10.1016/j.ebiom.2020.103015. Epub 2020 Sep 22.

An adequate human T cell repertoire from a single T cell progenitor: Lessons from an experiment of nature

Kirsten Canté-Barrett  1 , Frank J T Staal  2
Affiliations

An adequate human T cell repertoire from a single T cell progenitor: Lessons from an experiment of nature

Kirsten Canté-Barrett et al. EBioMedicine. 2020 Oct.
No abstract available

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Conflict of interest statement

Declaration of Interests Authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
Potential origin of the T cell progenitor (in red) with long-term self-renewal ability.
See this image and copyright information in PMC

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References

    1. Garcia-Perez L, Famili F, Cordes M, Brugman M, van Eggermond M, Wu H. Functional definition of a transcription factor hierarchy regulating T cell lineage commitment. Sci Adv. 2020;6(31):eaaw7313. - PMC - PubMed
    1. Rothenberg EV. Programming for T-lymphocyte fates: modularity and mechanisms. Genes Dev. 2019;33(17-18):1117–1135. - PMC - PubMed
    1. Brugman MH, Wiekmeijer AS, van Eggermond M, Wolvers-Tettero I, Langerak AW, de Haas EF. Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus. Proc Natl Acad Sci U S A. 2015;112(44):E6020–E6027. - PMC - PubMed
    1. Kury P, Führer M, Fuchs S, Lorenz MR, Giorgetti OB, Bakhtiar S. Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development. EBioMedicine. 2020;59 - PMC - PubMed
    1. Wiekmeijer AS, Pike-Overzet K, H IJ, Brugman MH, Wolvers-Tettero IL, Lankester AC. Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells. J Allergy Clin Immunol. 2016;137(2) 517-26.e3. - PubMed

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