Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep 23;7(4):143.
doi: 10.3390/vetsci7040143.

Involvement of Various Enzymes in the Physiology and Pathogenesis of Streptococcus suis

Chengkun Zheng  1   2 , Man Wei  1   2 , Mengdie Jia  1   2 , ManMan Cao  3
Affiliations
Review

Involvement of Various Enzymes in the Physiology and Pathogenesis of Streptococcus suis

Chengkun Zheng et al. Vet Sci. .

Abstract

Streptococcus suis causes severe infections in both swine and humans, making it a serious threat to the swine industry and public health. Insight into the physiology and pathogenesis of S. suis undoubtedly contributes to the control of its infection. During the infection process, a wide variety of virulence factors enable S. suis to colonize, invade, and spread in the host, thus causing localized infections and/or systemic diseases. Enzymes catalyze almost all aspects of metabolism in living organisms. Numerous enzymes have been characterized in extensive detail in S. suis, and have shown to be involved in the pathogenesis and/or physiology of this pathogen. In this review, we describe the progress in the study of some representative enzymes in S. suis, such as ATPases, immunoglobulin-degrading enzymes, and eukaryote-like serine/threonine kinase and phosphatase, and we highlight the important role of various enzymes in the physiology and pathogenesis of this pathogen. The controversies about the current understanding of certain enzymes are also discussed here. Additionally, we provide suggestions about future directions in the study of enzymes in S. suis.

Keywords: Streptococcus suis; enzymes; pathogenesis; physiology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Gene regulation and functions of S-ribosylhomocysteinase (LuxS) in S. suis. LuxS is positively regulated by small RNA rss04. LuxS regulates the expression of multiple genes associated with various phenotypes of S. suis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Goyette-Desjardins G., Auger J.P., Xu J., Segura M., Gottschalk M. Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing. Emerg. Microbes Infect. 2014;3:e45. doi: 10.1038/emi.2014.45. - DOI - PMC - PubMed
    1. Lun Z.R., Wang Q.P., Chen X.G., Li A.X., Zhu X.Q. Streptococcus suis: An emerging zoonotic pathogen. Lancet Infect. Dis. 2007;7:201–209. doi: 10.1016/S1473-3099(07)70001-4. - DOI - PubMed
    1. Zhang B., Ku X., Yu X., Sun Q., Wu H., Chen F., Zhang X., Guo L., Tang X., He Q. Prevalence and antimicrobial susceptibilities of bacterial pathogens in Chinese pig farms from 2013 to 2017. Sci. Rep. 2019;9:9908. doi: 10.1038/s41598-019-45482-8. - DOI - PMC - PubMed
    1. Wertheim H.F., Nghia H.D., Taylor W., Schultsz C. Streptococcus suis: An emerging human pathogen. Clin. Infect. Dis. 2009;48:617–625. doi: 10.1086/596763. - DOI - PubMed
    1. Tang J., Wang C., Feng Y., Yang W., Song H., Chen Z., Yu H., Pan X., Zhou X., Wang H., et al. Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med. 2006;3:e151. - PMC - PubMed

LinkOut - more resources