Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;41(2):286-294.
doi: 10.1038/s41372-020-00821-w. Epub 2020 Sep 25.

Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants

Courtney D Thornburg  1   2   3 , Stephen W Erickson  4 , Grier P Page  5 , Erin A S Clark  5 , Margaret M DeAngelis  5 , M Elizabeth Hartnett  6 , Ricki F Goldstein  7   6 , John M Dagle  8 , Jeffrey C Murray  8 , Brenda B Poindexter  9   10 , Abhik Das  11 , C Michael Cotten  7 ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Affiliations

Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants

Courtney D Thornburg et al. J Perinatol. 2021 Feb.

Erratum in

Abstract

Objective: To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study.

Study design: Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis.

Result: One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development.

Conclusion: Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest The authors have no conflict of interest to report. The contents of this report represent the views of the authors and do not represent the views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network or the National Institutes of Health.

Figures

Fig. 1
Fig. 1. LocusZoom plot of IGFR1.
The plot includes the local association results including rs1810225, rs1513643, and rs12442623; information about the location and orientation of the gene on chr15; linkage disequilibrium with rs12442623 (r2 color-coded according to inset legend); and local estimates of recombination rates (cM/Mb, blue line).
See this image and copyright information in PMC

References

    1. Sherlock RL, Anderson PJ, Doyle LW, Victorian Infant Collaborative Study G. Neurodevelopmental sequelae of intraventricular haemorrhage at 8 years of age in a regional cohort of ELBW/very preterm infants. Early Hum Dev. 2005;81:909–16. - PubMed
    1. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 2015;314:1039–51. - PMC - PubMed
    1. Bhandari V, Bizzarro MJ, Shetty A, Zhong X, Page GP, Zhang H, et al. Familial and genetic susceptibility to major neonatal morbidities in preterm twins. Pediatrics. 2006;117:1901–6. - PubMed
    1. Petaja J, Hiltunen L, Fellman V. Increased risk of intraventricular hemorrhage in preterm infants with thrombophilia. Pediatr Res. 2001;49:643–6. - PubMed
    1. Ramenghi LA, Fumagalli M, Groppo M, Consonni D, Gatti L, Bertazzi PA, et al. Germinal matrix hemorrhage: intraventricular hemorrhage in very-low-birth-weight infants: the independent role of inherited thrombophilia. Stroke. 2011;42:1889–93. - PubMed

Publication types