Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;34(1):e14343.
doi: 10.1111/dth.14343. Epub 2020 Oct 8.

Platelet-rich plasma-Where do we stand today? A critical narrative review and analysis

Gulhima Arora  1   2 , Sandeep Arora  1   2
Affiliations
Review

Platelet-rich plasma-Where do we stand today? A critical narrative review and analysis

Gulhima Arora et al. Dermatol Ther. 2021 Jan.

Abstract

"Sometimes you have to travel a long way to find what is near." This quote by Paulo Coelho stands true for platelet-rich plasma (PRP) as we know of it today. Large strides have been made to understand this "youth" in blood, but there still seems a long way to go in our understanding of it. Despite advances, clarity in its preparation, biology, and the properties of the final product still remains elusive. The concepts of an ideal number or concentration of platelets in the final enriched plasma, best devices to prepare PRP, an ideal hardware, standard parameters for its preparation, the need for its activation or buffering of the final preparation or whether anticoagulants should be used or not, have evolved, since it was first described. The authors present an analysis of PRP present day status and its usefulness in field of medicine with a review of published literature from "Medline" (via "PubMed"), "Cochrane," the Virtual Health Library, and Google Scholar related to PRP, its biology, types, and classifications, preparation, and use.

Keywords: platelet-rich fibrin; platelet-rich plasma; regenerative medicine.

PubMed Disclaimer

References

REFERENCES

    1. Alves R, Grimalt R. A review of Platelet-Rich Plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4:18-24.
    1. Ferrari M, Zia S, Valbonesi M, et al. A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int J Artif Organs. 1987;10:47-50.
    1. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001;10:225-228.
    1. Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author's perspective. J Cutan Aesthetic Surg. 2014;7:189-197.
    1. Crescente M, Pluthero FG, Li L, et al. Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arterioscler Thromb Vasc Biol. 2016;36:1164-1173.

LinkOut - more resources