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. 2021 Feb 26;51(1):335-341.
doi: 10.3906/sag-2005-331.

What is the predictive value of preoperative CA 125 level on the survival rate of type 1 endometrial cancer?

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What is the predictive value of preoperative CA 125 level on the survival rate of type 1 endometrial cancer?

Şafak Yilmaz Baran et al. Turk J Med Sci. .

Abstract

Background/aim: To investigate the utility of preoperative serum cancer antigen 125 (CA 125) levels in type 1 endometrial carcinoma (EC) as a marker for determining poor prognostic factors and survival.

Material and methods: All patients with endometrial cancer, who had been treated between 2012 and 2020, were retrospectively reviewed, and finally, 256 patients with type 1 endometrium carcinoma were included in the study. The relationship between the clinicopathological characteristics, CA 125 level, and survival rates were analyzed. The cut-off value for the preoperative serum CA 125 level was defined as 16 IU/L.

Results: The median serum CA 125 levels were significantly higher in patients with deep myometrial invasion, lymph node metastasis, lymphovascular space invasion, cervical stromal and adnexal involvement, advanced stage, positive peritoneal cytology, recurrence, and adjuvant therapy requirement. Serum CA 125 cut-off values determined according to clinicopathologic factors ranged from 15.3 to 22.9 IU/L (sensitivity 61%–77%, specificity 52%–73%). The disease-specific survival rate was significantly higher in patients with CA 125 levels < 16 IU/L (P = 0.047).

Conclusion: The data showed that choosing a lower threshold value for the CA 125 level (16 IU/L) instead of 35 IU/L, could be more useful in type 1 EC patients with negative prognostic factors.

Keywords: cut-off value; endometrial carcinoma; prognosis; survival; Cancer antigen 125 (CA 125).

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure
Figure
Disease-specific survival of the type 1 endometrial cancer patients with and without elevated CA 125 when cut-off is16 IU/L.

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