Review
doi: 10.1111/j.1600-065x.1987.tb00513.x.
Evolution of antibody variable region structure during the immune response
- PMID: 3298006
- DOI: 10.1111/j.1600-065x.1987.tb00513.x
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Review
Evolution of antibody variable region structure during the immune response
Immunol Rev.
1987 Apr.
Abstract
The results reviewed above reveal that during the anti-Ars immune response of strain A mice a somatic process that results in the evolution of V region structure occurs. This process involves both the selection of V regions encoded by particular gene segment combinations as well as the selection of structural variants of these V regions produced by somatic mutation as the immune response progresses. As a result, both quantitative and qualitative changes in the V region population initially elicited by immunization take place. The structural and functional character of the immune V region repertoire appears to be largely determined by this process of "somatic evolution" occurring in the primary response.
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