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Comment
. 2020 Dec;36(12):897-899.
doi: 10.1016/j.tig.2020.09.009. Epub 2020 Sep 23.

Current Techniques for Complex Phenotypes: GWAS of the Electrocardiogram

Eric B Fauman  1
Affiliations
Comment

Current Techniques for Complex Phenotypes: GWAS of the Electrocardiogram

Eric B Fauman. Trends Genet. 2020 Dec.

Abstract

By sampling 500 time points of an electrocardiogram (ECG) trace in a genome-wide association study (GWAS), Verweig et al. identified novel correlates for cardiac dysfunction. Clustering of SNPs based on their impact at all time points revealed natural sets of SNPs with similar effects and mechanisms. Similar approaches may be applicable to other quantitative, time-ordered traits.

Keywords: BAG3; ECG; GWAS; pleiotropy.

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Comment on

  • The Genetic Makeup of the Electrocardiogram.
    Verweij N, Benjamins JW, Morley MP, van de Vegte YJ, Teumer A, Trenkwalder T, Reinhard W, Cappola TP, van der Harst P. Verweij N, et al. Cell Syst. 2020 Sep 23;11(3):229-238.e5. doi: 10.1016/j.cels.2020.08.005. Epub 2020 Sep 10. Cell Syst. 2020. PMID: 32916098 Free PMC article.

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