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Review
. 2020 Dec;6(12):1044-1058.
doi: 10.1016/j.trecan.2020.08.004. Epub 2020 Sep 23.

Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer

Alpaslan Tasdogan  1 , David G McFadden  2 , Prashant Mishra  3
Affiliations
Review

Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer

Alpaslan Tasdogan et al. Trends Cancer. 2020 Dec.

Abstract

Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biological heterogeneity observed in human tumors. In this review, we summarize our current understanding of the role of mtDNA genetics in relation to human cancers.

Keywords: cancer; haplotypes; mitochondria; mtDNA; oncocytoma.

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