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. 2020 Oct:60:103003.
doi: 10.1016/j.ebiom.2020.103003. Epub 2020 Sep 24.

Glycosylation tips the scales: Novel insights into the dual role of type-I interferons in treated HIV infection

Marie-Kristin Raulf  1 , Bernd Lepenies  2
Affiliations

Glycosylation tips the scales: Novel insights into the dual role of type-I interferons in treated HIV infection

Marie-Kristin Raulf et al. EBioMedicine. 2020 Oct.
No abstract available

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Figures

Fig. 1:
Fig. 1
Giron and colleagues show that differential glycosylation of IgG and immune cell surface glycome in INFα-treated HIV patients correlate with altered immune functions. Pegylated (Peg)-IFNα2a treatment of ART-suppressed HIV infection affects host glycosylation machinery leading to enrichment of bisecting GlcNAc glycans on IgG and differential surface glycosylation of CD8+T cells and NK cells. Higher levels of bisecting GlcNAc glycans on IgG molecules may enhance binding to Fcγ receptors (FcγR) and lead to a higher abundance of the soluble monocyte/macrophage activation markers sCD14 and sCD163. Exacerbated inflammation is associated with suppressed CD8+T cell and NK cell effector functions. Consistently, IFNα-mediated reduction of genome-integrated HIV DNA is decreased. Altered surface glycosylation of CD8+T cells has counteractive effects on CD8+T cell functions. While higher levels of immunosuppressive GalNAc-containing glycans in CD8+T cell surface glycome may negatively impact the transcription factors T-bet and Eomes and perforin secretion, low sialic acid glycans are positively associated with these functions. Similarly, changes in NK cell surface glycome have counteractive effects on NK cell functions. This Figure was created using Servier Medical Art (http://smart.servier.com), licensed under a Creative Commons Attribution 3.0 Unported License.
See this image and copyright information in PMC

References

    1. Trinchieri G. Type I interferon: friend or foe? J Exp Med. 2010;207(10):2053–2063. - PMC - PubMed
    1. Wang B., Kang W., Zuo J., Kang W., Sun Y. The significance of type-I Interferons in the pathogenesis and therapy of human immunodeficiency virus 1 infection. Front Immunol. 2017;8:1431. - PMC - PubMed
    1. Cheng L., Ma J., Li J. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs. J Clin Invest. 2017;127(1):269–279. - PMC - PubMed
    1. Azzoni L., Foulkes A.S., Papasavvas E. Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J Infect Dis. 2013;207(2):213–222. - PMC - PubMed
    1. Murira A., Lamarre A. Type-I interferon responses: from friend to foe in the battle against chronic viral infection. Front Immunol. 2016;7:609. - PMC - PubMed

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