Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;25(4):2479-2486.
doi: 10.1007/s11030-020-10145-8. Epub 2020 Sep 27.

Visible-light-mediated one-pot efficient synthesis of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles: a metal-free photochemical approach in aqueous ethanol

Mohd Nazeef  1 , Km Neha Shivhare  1 , Shabir Ali  2 , Saif Ansari  1 , I R Siddiqui  3
Affiliations

Visible-light-mediated one-pot efficient synthesis of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles: a metal-free photochemical approach in aqueous ethanol

Mohd Nazeef et al. Mol Divers. 2021 Nov.

Abstract

A new metal-free approach to construct medicinally valuable 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles under visible light irradiation in aqueous ethanol medium at room temperature has been developed. The present process was performed with 1,2-phenylenediamines, aromatic aldehydes and 2-mercaptoacetic acid utilizing a simple household 22 W compact fluorescent lamp to generate C-S, C-N bonds through radical intermediates. This visible-light-promoted synthesis provides lower cost, operation simplicity and high functional groups tolerating ability with short reaction time and high yield under mild reaction conditions.

Keywords: 1-Aryl-1H,3H-thiazolo[3,4-a]benzimidazoles; Ethanol–water; Green synthesis; Metal-free; Visible light.

PubMed Disclaimer

References

    1. Martins P, Jesus J, Santos S, Raposo LR, Rodrigues CR, Baptista PV, Fernandes AR (2015) Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine’s tool Box. Molecules 20:16852. https://doi.org/10.3390/molecules200916852 - DOI - PubMed - PMC
    1. Asadi P, Khodarahmi G, Jahanian-Najafabadi A, Saghaie L, Hassanzadeh F (2017) Biologically active heterocyclic hybrids based on quinazolinone, benzofuran and imidazolium moieties: synthesis, characterization, cytotoxic and antibacterial evaluation. Chem Biodivers 14:1600411. https://doi.org/10.1002/cbdv.201600411 - DOI
    1. El-Gohary NS, Shaaban MI (2017) Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. Eur J Med Chem 131:255. https://doi.org/10.1016/j.ejmech.2017.03.018 - DOI - PubMed
    1. Tahlan S, Kumar S, Narasimhan B (2019) Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review. BMC Chem 13:101. https://doi.org/10.1186/s13065-019-0625-4 - DOI - PubMed - PMC
    1. Salahuddin Shaharyar M, Mazumder A (2017) Benzimidazoles: a biologically active compounds. Arab J Chem 10:S157. https://doi.org/10.1016/j.arabjc.2012.07.017 - DOI

LinkOut - more resources