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Case Reports
. 2020 May 28;8(9):1672-1677.
doi: 10.1002/ccr3.2985. eCollection 2020 Sep.

Extra-CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Sami Alhoulaiby  1 , Ali Abdulrahman  2 , Ghazal Alouni  2 , Mufed Mahfoud  3 , Zuhair Shihabi  4
Affiliations
Case Reports

Extra-CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Sami Alhoulaiby et al. Clin Case Rep. .

Abstract

Extra CNS metastasis of glioblastoma multiforme is extremely rare. We report a case of a 53-year-old Caucasian male who, after undergoing surgical resection and nine months adjuvant therapy, had a recurrence of the cancer with an infiltration expanding outside the cranium to the left maxilla, mandible and parotid gland.

Keywords: extra‐CNS metastasis; glioblastoma; lymph node metastasis; neurosurgery; parotid gland metastasis.

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Conflict of interest statement

We declare no competing interests.

Figures

FIGURE 1
FIGURE 1
Pathology of the brain tumor showing: (A) Diffuse proliferation of variable sized anaplastic cells occurring in small groups and isolated forms with large round or elongated hyperchromatic nuclei, and occasional bizarre mitotic figures (H&E ×200). B, Higher magnification with scattered foci of necrosis (H&E ×400)
FIGURE 2
FIGURE 2
MRI 4 mo after the surgery showing the area of the lesion with residual edema with no midline deviation nor ventricular compression on transverse T2 TSE images (A and B) and coronal FLAIR image (C)
FIGURE 3
FIGURE 3
Pathological microscopic images of the lymph node biopsy showing: invasive proliferating anaplastic cells, large hyperchromatic nuclei and occasional bizarre mitotic figures, with no identified residual lymphoid tissue
FIGURE 4
FIGURE 4
Immune staining of the lymph node biopsy confirming the GBM origin with positive GFAP staining (on the left) and negative CK staining (on the right)
See this image and copyright information in PMC

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